18.2 Friedel Crafts Alkylation and Acylation

Course Menu
CHECK OUT CHAD'S
PRE-HEALTH PREP
Table of Contents
    Add a header to begin generating the table of contents

    Friedel-Crafts Alkylation

    EAS Reaction / Reagents Electrophile Name
    eas reaction 12 electrophile 12 Friedel-Crafts Alkylation
    Characteristics of Friedel-Crafts Alkylations
    -Fails with moderately and strongly deactivated benzenes (still works with a halogenated benzene) friedel-crafts alkylations 01
    -Carbocation rearrangements are possible friedel-crafts alkylations 02
    -Alkylation activates the ring: multiple alkylations are hard to avoid friedel-crafts alkylations 03
    EAS Reaction / Reagents Electrophile Name
    eas reaction 13 electrophile 13 Friedel-Crafts Acylation

    Friedel-Crafts Acylation

    Characteristics of Friedel-Crafts Acylations
    -Fails with moderately and strongly deactivated benzenes (still works with a halogenated benzene) friedel-crafts acylations 01
    -Carbocation rearrangements don’t occur
    -Generally occurs only once
    -Favors para if ortho/para director is on benzene due to bulkiness
    -Formylation (Gattermann-Koch Synthesis) is a special case friedel-crafts acylations 02