21.4 Alpha Alkylation (including the Stork Reaction)

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Alpha Alkylation with LDA

-SN2 reaction with an enolate attacking an alkyl halide

alpha alkylation with LDA
alpha alkylation with LDA 02

Stork Reaction

-Alternative method of alpha alkylation

1. ketone is first converted to an enamine

2. alkylation occurs with the enamine followed by

3. hydrolysis back to a ketone

stork reactio